Simulation of aqueous humour (ah) flows and deformation of descement membrane detachment (dmd) in a three dimensional anterior chamber (ac)

Abstract

This thesis strives the interaction between the aqueous humour (AH) flows and the deformation of Descemet membrane detachment (DMD) in a 3D anterior chamber (AC). Descemet membrane detachment (DMD) is an uncomman condition with a wide range of possible cause of disease. The aqueous humour flow in the anterior chamber is described as flow driven by buoyancy effects due to the existing temperature difference. The mathematical model has been developed and numerical result for finite element method are carried out using COMSOL Multiphysics software by solving the governing equations for the AH flows and the deformation of DMD. The fluid flow behavior and the deformation of the detached Descemet membrane are analysed in order to comprehend the progression of the DMD in the AC due to the AH flows and vice versa. The direction of the gravitational force acting has a great influence to the fluid flow in the AC. Thus, the position of the patient with DMD need to be concerned in order to induce the phenomena of spontaneous reattachment. The spontaneous attachment or re-detachment of the DMD could then be induced in the simulation to better understand its occurrence for a viable treatment to be devised.