Homology modeling of human sweet taste receptors: T1R2-T1R3

Abstract

The sweet taste perception in human is mainly due to the specific G protein- copulated heterodimeric receptors (GPCR) T1R2-T1R3 and these receptors gathered in the taste buds of the tongue. The sweet protein acts as an important rule for molecular understanding of the taste mechanisms. Therefore, the Homology modeling of the closely related sweet taste receptors (T1R2-T1R3), is crucial to provide an understanding of the interactions between the sweetens and the receptors. 3A21 and 3Q41 were selected as possible templates for T1R2 and T1R3, respectively based on the phylogenetic evaluations. The models of the target sequences were generated using the program MODELLER V9.10. From the Ramachandran plot analysis it was shown that 79% and 84% of the residues reside in the core region for T1R2 model and T1R3 model, respectively.