Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line

Abstract

The purpose of this study is to investigate the application of genetic algorithm (GA) in modelling linear and non-linear dynamic systems and develop an alternative model structure selection algorithm based on GA. Orthogonal least square (OLS), a gradient descent method was used as the benchmark for the proposed algorithm. A model structure selection based on modified genetic algorithm (MGA) has been proposed in this study to reduce problems of premature convergence in simple GA (SGA). The effect of different combinations of MGA operators on the performance of the developed model was studied and the effectiveness and shortcomings of MGA were highlighted. Results were compared between SGA, MGA and benchmark OLS method. It was discovered that with similar number of dynamic terms, in most cases, MGA performs better than SGA in terms of exploring potential solution and outperformed the OLS algorithm in terms of selected number of terms and predictive accuracy. In addition, the use of local search with MGA for fine-tuning the algorithm was also proposed and investigated, named as memetic algorithm (MA). Simulation results demonstrated that in most cases, MA is able to produce an adequate and parsimonious model that can satisfy the model validation tests with significant advantages over OLS, SGA and MGA methods. Furthermore, the case studies on identification of multivariable systems based on real experiment t al data from two systems namely a turbo alternator and a continuous stirred tank reactor showed that the proposed algorithm could be used as an alternative to adequately identify adequate and parsimonious models for those systems. Abstract must be bilingual. For a thesis written in Bahasa Melayu, the abstract must first be written in Bahasa Melayu and followed by the English translation. If the thesis is written in English, the abstract must be written in English and followed by the translation in Bahasa Melayu. The abstract should be brief, written in one paragraph and not exceed one (1) page. An abstract is different from synopsis or summary of a thesis. It should states the field of study, problem definition, methodology adopted, research process, results obtained and conclusion of the research. The abstract can be written using single or one and a half spacing. Example can be seen in Appendix 1 (Bahasa Melayu) and Appendix J (English).