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Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters

Lukman, Siti Khadijah and Al-Ashwal, Rania Hussein and Sultana, Naznin and Saidin, Syafiqah (2019) Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters. Chemical and Pharmaceutical Bulletin, 67 (5). pp. 445-451. ISSN 0009-2363

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Official URL: http://dx.doi.org/10.1248/cpb.c18-00847

Abstract

Electrodeposition is commonly used to deposit ceramic or metal coating on metallic implants. Its utilization in depositing polymer microcapsule coating is currently being explored. However, there is no encapsulation of drug within polymer microcapsules that will enhance its chemical and biological properties. Therefore, in this study, ginseng which is known for its multiple therapeutic effects was encapsulated inside biodegradable poly(lactic-co-glycolic acid) (PLGA) microcapsules to be coated on pre-treated medical grade stainless steel 316L (SS316L) using an electrodeposition technique. Polyaniline (PANI) was incorporated within the microcapsules to drive the formation of microcapsule coating. The electrodeposition was performed at different current densities (1–3mA) and different deposition times (20–60s). The chemical composition, morphology and wettability of the microcapsule coatings were characterized through attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and contact angle analyses. The changes of electrolyte colors, before and after the electrodeposition were also observed. The addition of PANI has formed low wettability and uniform microcapsule coatings at 2mA current density and 40s deposition time. Reduction in the current density or deposition time caused less attachment of microcapsule coatings with high wettability records. While prolonging either one parameter has led to debris formation and melted microcapsules with non-uniform wettability measurements. The color of electrolytes was also changed from milky white to dark yellow when the current density and deposition time increased. The application of tolerable current density and deposition time is crucial to obtain a uniform microcapsule coating, projecting a controlled release of encapsulated drug.

Item Type:Article
Uncontrolled Keywords:electrodeposition, microcapsule coating, panax ginseng
Subjects:T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TP Chemical technology
Divisions:Biosciences and Medical Engineering
ID Code:87733
Deposited By: Yanti Mohd Shah
Deposited On:30 Nov 2020 13:15
Last Modified:30 Nov 2020 13:15

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