Sathishkumar, Palanivel and Vennila, Krishnan and Jayakumar, Rajarajeswaran and Mohd. Yusoff, Abdull Rahim and Hadibarata, Tony and Palvannan, Thayumanavan (2016) Phyto-synthesis of silver nanoparticles using Alternanthera tenella leaf extract: an effective inhibitor for the migration of human breast adenocarcinoma (MCF-7) cells. Bioprocess and Biosystems Engineering, 39 (4). pp. 651-659. ISSN 1615-7591
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Abstract
In this study, phyto-synthesis of silver nanoparticles (AgNPs) was achieved using an aqueous leaf extract of Alternanthera tenella. The phytochemical screening results revealed that flavonoids are responsible for the AgNPs formation. The AgNPs were characterised using UV-visible spectrophotometer, field emission scanning microscopy/energy dispersive X-ray, transmission electron microscopy, fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction. The average size of the nanoparticles was found to be ≈48 nm. The EDX results show that strong signals were observed for the silver atoms. The strong band appearing at 1601-1595 cm-1 correspond to C-C stretching vibration from dienes in FT-IR spectrum indicating the formation of AgNPs. Human breast adenocarcinoma (MCF-7) cells treated with various concentrations of AgNPs showed a dose-dependent increase in cell inhibition. The IC50 value of the AgNPs was calculated to be 42.5 μg mL-1. The AgNPs showed a significant reduction in the migration of MCF-7 cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cells, Cytology, Flavonoids, Fourier transform infrared spectroscopy, High resolution transmission electron microscopy, Metal nanoparticles, Nanoparticles, Scanning electron microscopy, Stretching, Synthesis (chemical), Transmission electron microscopy, X ray diffraction, Adenocarcinoma cells, Alternanthera tenella, Anticancer activities, Cell migration, Silver nanoparticles, Silver, Alternanthera tenella extract, antineoplastic agent, flavonoid, plant extract, silver nanoparticle, unclassified drug, metal nanoparticle, plant extract, silver, Alternanthera, Alternanthera tenella, antineoplastic activity, aqueous solution, Article, cancer inhibition, cell migration assay, controlled study, field emission scanning electron microscopy, human, human cell, IC50, infrared spectroscopy, MCF 7 cell line, nonhuman, phytochemistry, phytosynthesis, plant leaf, priority journal, synthesis, ultraviolet spectrophotometry, vibration, X ray, adenocarcinoma, Amaranthaceae, breast tumor, cell motion, chemistry, drug effects, female, MCF-7 cell line, metabolism, pathology, Adenocarcinoma, Amaranthaceae, Breast Neoplasms, Cell Movement, Female, Humans, MCF-7 Cells, Metal Nanoparticles, Plant Extracts, Plant Leaves, Silver |
| Subjects: | T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Civil Engineering |
| ID Code: | 72742 |
| Deposited By: | Siti Nor Hashidah Zakaria |
| Deposited On: | 27 Nov 2017 09:02 |
| Last Modified: | 27 Nov 2017 09:02 |
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