Universiti Teknologi Malaysia Institutional Repository

Fabrication and application of nanofork for measuring single cells adhesion force inside ESEM

Ahmad, Mohd. Ridzuan and Nakajima, Masahiro and Kojima, Masaru and Kojima, Seiji and Homma, Michio and Fukuda, Toshio (2011) Fabrication and application of nanofork for measuring single cells adhesion force inside ESEM. Enabling Science and Nanotechnology, 1341 . pp. 304-308. ISSN 1743-3509

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Abstract

In this paper, single cell adhesion force was measured using a nanofork. The nanofork was used to pick-up a single cell on a line-patterned substrate inside ESEM. The line-patterned substrate was used to provide small gaps between the single cells and the substrate. Therefore, the nanofork could be inserted through these gaps in order to successfully pick-up a single cell. Adhesion force was measured during the cell pick-up process from the deflection of the cantilever beam. The nanofork was fabricated using focused ion beam (FIB) etching process while the line-patterned substrate was fabricated using nanoimprinting technology. As to investigate the effect of contact area on the strength of the adhesion force, two sizes of gap distance of line-patterned substrate were used, i.e. 1 µm and 2 µm. Results showed that cells attached on the 1 µm gap line-patterned substrate required more force to be released as compared to the cells attached on the 2 µm gap line-patterned substrate.

Item Type:Article
Uncontrolled Keywords:measuring single cells
Subjects:Q Science > QH Natural history
Divisions:Electrical Engineering
ID Code:44921
Deposited By: Pn Haliza Zainal
Deposited On:21 Apr 2015 03:31
Last Modified:18 Sep 2017 01:15

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