Mohd. Sirat, Hasnah (2010) Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood. Journal of Natural Medicines, 64 (3). pp. 365-369.
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Official URL: http://dx.doi.org/10.1007/s11418-010-0410-0
Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC50 value of 100.9 lM. It also showed strong inhibition against ADP-induced aggregation, with an IC50 value of 57.1 lM. Isobavachalcone, 20,40-dihydroxy-4-methoxy-30-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation,with IC50 values ranging from55.3 to 192.0 lM, but did not show such effect against other inducers
|Uncontrolled Keywords:||Artocarpus species, Antiplatelet aggregation, Human whole blood, Cycloheterophyllin, 20,40-dihydroxy-4-methoxy-30- prenyldihydrochalcone, Arachidonic acid|
|Deposited By:||Kamariah Mohamed Jong|
|Deposited On:||30 Apr 2012 09:02|
|Last Modified:||30 Apr 2012 09:02|
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