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Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin-induced type 1 diabetes in rats

Alomari, Ghada and Al-Trad, Bahaa and Hamdan, Salehhuddin and Aljabali, Alaa A. A. and Al Zoubi, Mazhar Salim and Al-Batanyeh, Khalid and Qar, Janti and Eaton, Gregory J. and Alkaraki, Almuthanna K. and Alshaer, Walhan and Haifawi, Saja and Jemon, Khairunadwa and Chellappan, Dinesh Kumar and Dua, Kamal and Tambuwala, Murtaza M. (2021) Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin-induced type 1 diabetes in rats. IET Nanobiotechnology, 15 (5). pp. 473-483. ISSN 1751-8741


Official URL: http://dx.doi.org/10.1049/nbt2.12026


This study examines the effect of nanoparticles with zinc oxides (ZnONPs) on diabetic nephropathy, which is the primary cause of mortality for diabetic patients with end-stage renal disease. Diabetes in adult male rats was induced via intraperitoneal injection of streptozotocin. ZnONPs were intraperitoneally administered to diabetic rats daily for 7 weeks. Diabetes was associated with increases in blood glucose level, 24-h urinary albumin excretion rate, glomerular basement membrane thickness, renal oxidative stress markers, and renal mRNA or protein expression of transforming growth factor-ß1, fibronectin, collagen-IV, tumour necrosis factor-a and vascular endothelial growth factor-A. Moreover, the expression of nephrin and podocin, and the mRNA expression of matrix metalloproteinase-9 were decreased in the diabetic group. These changes were not detected in the control group and were significantly prevented by ZnONP treatment. These results provide evidence that ZnONPs ameliorate the renal damage induced in a diabetic rat model of nephropathy through improving renal functionality; inhibiting renal fibrosis, oxidative stress, inflammation and abnormal angiogenesis; and delaying the development of podocyte injury. The present findings may help design the clinical application of ZnONPs for protection against the development of diabetic nephropathy.

Item Type:Article
Uncontrolled Keywords:diabetic nephropathy, streptozotocin
Subjects:R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:97913
Deposited By: Widya Wahid
Deposited On:10 Nov 2022 08:55
Last Modified:10 Nov 2022 08:55

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