Universiti Teknologi Malaysia Institutional Repository

Two-dimensional signal transduction during the formation of invadopodia

Noor Azhuan, N. A. and Poignard, C. and Suzuki, T. and Shafie, S. and Admon, M. A. (2019) Two-dimensional signal transduction during the formation of invadopodia. Malaysian Journal of Mathematical Sciences, 13 (2). pp. 155-164. ISSN 1823-8343

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Official URL: https://einspem.upm.edu.my/journal/volume13.2may.p...


Signal transduction is an important process associated with invadopodia formation which consequently leads to cancer cell invasion. In this study, a two-dimensional free boundary problem in a steady-case of signal trans- duction during the formation of invadopodia is investigated. The signal equation is represented by a Laplace equation with Dirichlet boundary condition. The plasma membrane is taken as zero level set function. The level set method is used to solve the complete model numerically. Our results showed that protrusions are developed on the membrane surface due to the presence of signal density inside the cell.

Item Type:Article
Uncontrolled Keywords:Free boundary problem and Level set method, Invadopodia formation, Signal transduction
Subjects:Q Science > QA Mathematics
ID Code:96982
Deposited By: Widya Wahid
Deposited On:06 Sep 2022 15:53
Last Modified:06 Sep 2022 15:53

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