Zailani, Muhamad Zulhilmi and Ismail, Ahmad Fauzi and Goh, Pei Sean and Sheikh Abdul Kadir, Siti Hamimah and Othman, Mohd. Hafiz Dzarfan and Hasbullah, Hasrinah and Abdullah, Mohd. Sohaimi and Ng, Be Cheer and Kamal, Fatmawati (2021) Antioxidant and antithrombotic study of novel chitosan-diallyl disulfide inclusion complexes nanoparticles for hemodialysis applications. Reactive and Functional Polymers, 163 . ISSN 1381-5148
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Official URL: http://dx.doi.org/10.1016/j.reactfunctpolym.2021.1...
Abstract
Chitosan nanoparticles (CNP) is a biopolymer with good antioxidant and blood compatibility. However, its haemostatic nature limits its use for blood-contacting applications. This study aimed to investigate the antioxidant and anti-thrombogenic properties of complexes composed of CNP and diallyl disulfide (DADS). The formation of intramolecular hydrogen bonds proved possible bonding between CNP and DADS to form complexes. XRD spectra showed the complexes were amorphous. The in-vitro study revealed that CNP/DADS exhibits 29.5% NO and 32.8% HP inhibition which proved its antioxidant properties. APTT and PT test results proved that CNP/DADS's antithrombogenic properties (P < 0.001), making it a promising material for hemodialysis application.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chitosan nanoparticle, diallyl disulifide, hemocompatible |
| Subjects: | Q Science > Q Science (General) T Technology > TP Chemical technology |
| Divisions: | Chemical and Energy Engineering |
| ID Code: | 95665 |
| Deposited By: | Yanti Mohd Shah |
| Deposited On: | 31 May 2022 13:04 |
| Last Modified: | 31 May 2022 13:04 |
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