Universiti Teknologi Malaysia Institutional Repository

COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes

Al-Hatamleh, Mohammad A. I. and Hatmal, Ma'mon M. and Alshaer, Walhan and Engku A. Rahman, Engku Nur Syafirah and Mohd. Zahid, Manali Haniti and Alhaj-Qasem, Dina M. and Chan, Yean Yean and Alias, Iskandar Z. and Jaafar, Juhana and Ferji, Khalid and Six, Jean-Luc (2021) COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes. European Journal of Pharmacology, 896 . p. 173930. ISSN 0014-2999

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Official URL: http://dx.doi.org/10.1016/j.ejphar.2021.173930

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which emerged in December 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic, took the world by surprise with an unprecedented public health emergency. Since this pandemic began, extraordinary efforts have been made by scientists to understand the pathogenesis of COVID-19, and to fight the infection by providing various preventive, diagnostic and treatment opportunities based on either novel hypotheses or past experiences. Despite all the achievements, COVID-19 continues to be an accelerating health threat with no specifically approved vaccine or therapy. This review highlights the recent advances in COVID-19 infection, with a particular emphasis on nanomedicine applications that can help in the development of effective vaccines or therapeutics against COVID-19. A novel future perspective has been proposed in this review based on utilizing polymersome nano-objects for effectively suppressing the cytokine storm, which may reduce the severity of COVID-19 infection.

Item Type:Article
Uncontrolled Keywords:Cytokine storm, Nanomedicine
Subjects:T Technology > TP Chemical technology
ID Code:95086
Deposited By: Widya Wahid
Deposited On:29 Apr 2022 22:23
Last Modified:29 Apr 2022 22:23

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