Jibril, S. and Sirat, H. M. and Basar, N. and Wahab, R. A. and Mahat, N. A. and Wan Salleh, W. M. N. H. (2021) Ultrasonic-assisted rapid extraction of cassia sieberiana d.c.: a box-behnken design process optimisation. International Journal of Computational Biology and Drug Design, 14 (1). ISSN 1756-0756
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Official URL: http://dx.doi.org/10.1504/IJCBDD.2021.114092
Abstract
Ultrasonic-assisted extraction (UAE) on the Cassia sieberiana root was optimised by a three-factor-three-level Box-Behnken design (BBD). A single factor experiment revealed the logic ranges for the UAE parameters for extraction time, temperature and solvent to sample ratio were 10-60 min, 30-60 C and 10-30 mL/g, respectively. The BBD showed that a second-order polynomial model produced a satisfactory fitting of the experimental data (R2 = 0.9917, P < 0.001) with regards to extraction yield. The optimal UAE conditions were 29 min, 45 C and 16.79 mL/g. Under the optimised conditions, the UAE yielded 1.28 ± 0.7% of C. sieberiana root extract as to 0.69 ± 1.1% obtained by maceration and 0.82 ± 0.5% obtained by Soxhlet extraction. The results affirmed that the BBD was suitable in establishing the optimum UAE conditions for a maximum extraction yield while being more efficient and rapid than conventional methods (maceration and Soxhlet extraction).
Item Type: | Article |
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Uncontrolled Keywords: | Box-Behnken, Cassia sieberiana, design |
Subjects: | Q Science > QD Chemistry |
Divisions: | Science |
ID Code: | 95068 |
Deposited By: | Narimah Nawil |
Deposited On: | 29 Apr 2022 22:02 |
Last Modified: | 29 Apr 2022 22:02 |
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