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Ultrasonic-assisted rapid extraction of cassia sieberiana d.c.: a box-behnken design process optimisation

Jibril, S. and Sirat, H. M. and Basar, N. and Wahab, R. A. and Mahat, N. A. and Wan Salleh, W. M. N. H. (2021) Ultrasonic-assisted rapid extraction of cassia sieberiana d.c.: a box-behnken design process optimisation. International Journal of Computational Biology and Drug Design, 14 (1). ISSN 1756-0756

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Official URL: http://dx.doi.org/10.1504/IJCBDD.2021.114092

Abstract

Ultrasonic-assisted extraction (UAE) on the Cassia sieberiana root was optimised by a three-factor-three-level Box-Behnken design (BBD). A single factor experiment revealed the logic ranges for the UAE parameters for extraction time, temperature and solvent to sample ratio were 10-60 min, 30-60 C and 10-30 mL/g, respectively. The BBD showed that a second-order polynomial model produced a satisfactory fitting of the experimental data (R2 = 0.9917, P < 0.001) with regards to extraction yield. The optimal UAE conditions were 29 min, 45 C and 16.79 mL/g. Under the optimised conditions, the UAE yielded 1.28 ± 0.7% of C. sieberiana root extract as to 0.69 ± 1.1% obtained by maceration and 0.82 ± 0.5% obtained by Soxhlet extraction. The results affirmed that the BBD was suitable in establishing the optimum UAE conditions for a maximum extraction yield while being more efficient and rapid than conventional methods (maceration and Soxhlet extraction).

Item Type:Article
Uncontrolled Keywords:Box-Behnken, Cassia sieberiana, design
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:95068
Deposited By: Narimah Nawil
Deposited On:29 Apr 2022 22:02
Last Modified:29 Apr 2022 22:02

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