Evaluation of anti-diabetic activity of Carica papaya leaves extract using yeast cells method

Abstract

The present diabetes epidemic highlights the need for adequate and efficient drugs. The implementation of alternative and complementary medicinal products becomes a high priority. Many trials disclosed Carica papaya's anti-diabetic function, but its function in taking up glucose was not fully discovered. Therefore, this study aimed to evaluate the rate of glucose uptake across the cell membrane in the yeast cell system in the presence of C. papaya aqueous extract in different concentrations (1 mg, 2 mg, 3 mg, 4 mg, 5 mg) at different glucose concentrations (5 mM, 10 mM, 25 mM). The results showed that a linear improvement in the transport of glucose a cross yeast was comparable to Metformin at different glucose concentrations. The maximum glucose uptake was 76% in 5 mg of aqueous extract of C. papaya at 5 mM glucose concentration. The finding of this study may be useful for future research and the development of a new natural product to treat diabetes mellitus.