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Mechanical property, antibacterial activity and cytocompatibility of a PMMA-based bone cement loaded with clindamycin for orthopaedic surgeries

Pahlevanzadeh, F. and Bakhsheshi-Rad, H. R. and Kasiri-Asgarani, M. and Emadi, R. and Omidi, M. and Ismail, A. F. and Afrand, M. and Berto, F. (2020) Mechanical property, antibacterial activity and cytocompatibility of a PMMA-based bone cement loaded with clindamycin for orthopaedic surgeries. Materials Technology . ISSN 1066-7857

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Official URL: http://dx.doi.org/10.1080/10667857.2020.1780812

Abstract

Local delivery of antibiotics utilising bone cement is a well-known approach for controlling postoperative infections related to implant. 1, 5 and 10 wt.% of clindamycin (Cli) was embedded into polymethylmethacrylate (PMMA)–based bone cement for inhibiting postsurgical infection. Clindamycin antibiotic drug was homogeneously embedded into the matrix of PMMA-based cement. The results revealed that the fabricated PMMA-based cement loaded with Cli presented a high compressive strength (~120 MPa). The PMMA-based cement loaded with low Cli presented better cytocompatibility compared with its counterpart loaded with high Cli owing to the better cell attachment on the surface of the cement with a lower release of Cli. The embedding of Cli into the cement improved its antibacterial performance, as implied by the considerably improved inhibition zone with amplifying Cli concentration. Taken together, PMMA-based cement loaded with 1–5 wt% Cli might be a promising antimicrobial bone cement to be employed in orthopaedic surgeries.

Item Type:Article
Uncontrolled Keywords:antibacterial activity, biocompatibility
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:91180
Deposited By: Widya Wahid
Deposited On:21 Jun 2021 08:40
Last Modified:21 Jun 2021 08:40

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