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Optimization and isolation of 4,8,12,16-tetramethylheptadecan-4-olide from deinbollia pinnata

Rufai, Y. and Basar, N. and Sani, A. (2019) Optimization and isolation of 4,8,12,16-tetramethylheptadecan-4-olide from deinbollia pinnata. Asian Journal of Chemistry, 11 (31). ISSN 2503-2511


Official URL: http://www.dx.doi.org/10.14233/ajchem.2019.22165


Manual agitation on ultrasonic assisted extraction process, fractionation, isolation and purification afforded 4,8,12,16-tetramethylheptadecan-4-olide (1) along with 11 compounds 2-12 i.e., squalene (2), phytyl palmitate (3), lupeol (4), taraxasterol (5), myristic acid (6), palmitic acid (7), campesterol (8), stigmasterol (9), λ-sitosterol (10), stigmastan-3, 5-diene (11) and stigmasta-5,22-diene-3-ol acetate (12). Their structures were elucidated spectroscopically (2D NMR, IR, GC-MS and 1D NMR). The optimal conditions for high yield of extracts were obtained at 45 °C, after 35 min and solvent ratio 50:50 mL for 83.01 % yield; which was applied on agita-sonication process for bulk sample extraction of D. pinnata leaves with single solvent at a time. Thus, this work provides alternative method to overcome large sample extraction for phyto-constituents of isolation of 4,8,12,16-tetramethylheptadecan-4-olide (1) with ten other compounds from this specie pinnata and genius Deinbollia except stigmasterol (9).

Item Type:Article
Uncontrolled Keywords:deinbollia pinnata, isolation, optimization
Subjects:Q Science > QD Chemistry
ID Code:90941
Deposited By: Narimah Nawil
Deposited On:31 May 2021 21:21
Last Modified:31 May 2021 21:21

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