Abid, F. M. A. and Jamalis, J. and Chander, S. and Wahab, R. A. and Bhagwat, D. P. and Sankaranarayanan, M. (2019) Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues. Chemical Data Collections, 21 . ISSN 2405-8300
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Official URL: https://dx.doi.org/10.1016/j.cdc.2019.100219
Abstract
A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fungal activity against Candida albicans and Aspergillus niger using fluconazole as reference drug. The assay revealed that, compound 3k showed significant activity (14 mm ZOI, 64 µg/mL IC50 and 15 mm ZOI, >32 µg/mL IC50) against C. albicans and A. niger, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | thiazolidine, candida albicans, fluconazole |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Science |
| ID Code: | 89748 |
| Deposited By: | Narimah Nawil |
| Deposited On: | 22 Feb 2021 01:45 |
| Last Modified: | 22 Feb 2021 01:45 |
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