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Synthesis and in-vitro characterization of biodegradable porous magnesium-based scaffolds containing silver for bone tissue engineering

Bakhsheshi-Rad, Hamid Reza and Dayaghi, Ehsan and Ismail, Ahmad Fauzi and Aziz, Madzlan and Akhavan-Farid, Ali and Chen, Xiongbiao (2019) Synthesis and in-vitro characterization of biodegradable porous magnesium-based scaffolds containing silver for bone tissue engineering. Transactions of Nonferrous Metals Society of China (English Edition), 29 (5). pp. 984-996. ISSN 1003-6326

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Official URL: http://dx.doi.org/10.1016/S1003-6326(19)65007-7


Infection is a major potential complication in the clinical treatment of bone injuries. Magnesium (Mg)-based composites are biodegradable and antibacterial biomaterials that have been employed to reduce infection following surgical implants. The aim of present study was to synthesize and in-vitro characterize Mg-based scaffolds containing silver for bone tissue engineering. Porous Mg-based scaffolds with four silver concentrations (i.e., 0, 0.5 wt.%, 1 wt.%, and 2 wt.%), denoted by Mg–Ca–Mn–Zn–xAg (MCMZ–xAg) (where x is the silver concentration), were fabricated by the space holder technique. The effects of silver concentration on pore architecture, mechanical properties, bioactivity, and zone of bacterial inhibition were investigated in-vitro. X-ray diffractometry (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and fluorescence microscopy were utilized to characterize the obtained scaffolds. In-vitro corrosion test results indicated that the MCMZ scaffolds with lower silver content were more resistant to corrosion than those enriched with higher amounts of silver. Examination of the antibacterial activity showed that the MCMZ–Ag scaffolds exhibited superb potential with respect to suppressing the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), in the inhibition zone around the MCMZ–Ag scaffolds, with increasing in the amount of incorporated silver; however, higher amounts of silver increased the cytotoxicity. Taken together, the results of this study demonstrate that the porous 0.5 wt.% Ag-containing scaffolds with interconnected pores, adequate mechanical properties, antibacterial activity, and cell adhesion are promising with respect to the repair and substitution of damaged and diseased bones.

Item Type:Article
Uncontrolled Keywords:bioactivity, biocompatibility, corrosion behavior, Mg-based scaffold
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:89539
Deposited By: Yanti Mohd Shah
Deposited On:22 Feb 2021 14:08
Last Modified:22 Feb 2021 14:08

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