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Molecular docking and recent advances in the design and development of cholinesterase inhibitor scaffolds: Coumarin hybrids

Hasan, Aso Hameed and Amran, Syazwani Itri and Saeed Hussain, Faiq Hama and Ahmed Jaff, Baram and Jamalis, Joazaizulfazli (2019) Molecular docking and recent advances in the design and development of cholinesterase inhibitor scaffolds: Coumarin hybrids. ChemistrySelect, 4 (48). pp. 14140-14156. ISSN 2365-6549

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Official URL: http://dx.doi.org/10.1002/slct.201903607

Abstract

Alzheimer is a deadly neurodegenerative disease that commonly attacks elderly people around the world. Therefore, this disease has drawn attention among the researchers to find new potent drugs to treat Alzheimer disease (AD) more efficiently. Coumarin containing scaffold is a potential AD agent. Coumarin hybrids are frequently used as a template to design novel therapeutic agent for the treatment of AD, which are designed based on using molecular docking. As a result of docking studies shown that coumarin cores can occupy PAS by making extensive hydrophobic interactions with the residues in that region (mainly Trp279, Tyr70, Tyr121, Asp72, Phe290, Trp84, Phe330). The present review compiles research literature on the recent design strategies of coumarin hybrids with anti-Alzheimer's activities and outlined docking studies.

Item Type:Article
Uncontrolled Keywords:Coumarin, Molecular docking
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:89424
Deposited By: Widya Wahid
Deposited On:22 Feb 2021 01:47
Last Modified:22 Feb 2021 01:47

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