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A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering

Tang, Mei Shick and Abdul Kadir, Aini Zuhra and Nor Hasrul AkhmalNgadiman, Nor Hasrul AkhmalNgadiman and AzanizawatiMa’aram, AzanizawatiMa’aram (2019) A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering. Journal of Bioactive and Compatible Polymers, 34 (6). pp. 415-435. ISSN 0883-9115

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Official URL: http://dx.doi.org/10.1177/0883911519877426


The current developments in three-dimensional printing also referred as “additive manufacturing” have transformed the scenarios for modern manufacturing and engineering design processes which show greatest advantages for the fabrication of complex structures such as scaffold for tissue engineering. This review aims to introduce additive manufacturing techniques in tissue engineering, types of biomaterials used in scaffold fabrication, as well as in vitro and in vivo evaluations. Biomaterials and fabrication methods could critically affect the outcomes of scaffold mechanical properties, design architectures, and cell proliferations. In addition, an ideal scaffold aids the efficiency of cell proliferation and allows the movements of cell nutrient inside the human body with their specific material properties. This article provides comprehensive review that covers broad range of all the biomaterial types using various additive manufacturing technologies. The data were extracted from 2008 to 2018 mostly from Google Scholar, ScienceDirect, and Scopus using keywords such as “Additive Manufacturing,” “3D Printing,” “Tissue Engineering,” “Biomaterial” and “Scaffold.” A 10 years research in this area was found to be mostly focused toward obtaining an ideal scaffold by investigating the fabrication strategies, biomaterials compatibility, scaffold design effectiveness through computer-aided design modeling, and optimum printing machine parameters identification. As a conclusion, this ideal scaffold fabrication can be obtained with the combination of different materials that could enhance the material properties which performed well in optimum additive manufacturing condition. Yet, there are still many challenges from the printing methods, bioprinting and cell culturing that needs to be discovered and investigated in the future.

Item Type:Article
Uncontrolled Keywords:scaffold, tissue engineering
Subjects:T Technology > TJ Mechanical engineering and machinery
Divisions:Mechanical Engineering
ID Code:89182
Deposited By: Widya Wahid
Deposited On:26 Jan 2021 16:49
Last Modified:26 Jan 2021 16:49

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