Universiti Teknologi Malaysia Institutional Repository

Efficient magnetic microbeads trapping using lab-on-chip magnetic separator

Abidin, U. and Majlis, B. Y. and Yunas, J. (2019) Efficient magnetic microbeads trapping using lab-on-chip magnetic separator. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 57 (1). pp. 1-11. ISSN 2289-7879

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Lab-on-Chip (LoC) magnetic separation is a simple and effective method in separating bioparticles labelled with magnetic microbeads in microfluidics flow condition. In this work, trapping efficiency of magnetic microbeads using LoC magnetic separator and a microfluidics channel with chamber design is determined. The polydimethylsiloxane (PDMS) microfluidics channel was designed with an inlet, an outlet and a circular trapping chamber at the center. Standard soft lithography technique was used to replicate the PDMS microfluidics channel from the SU-8 mould. In a continuous hydrodynamics flow of 1.0 μL/min, trapping efficiency of 99.5 % and 94.9 % for 4.5 μm and 2.5 μm magnetic microbeads respectively was achieved. Flow analysis using COMSOL Multiphysics has been conducted in predicting the possible location of the magnetic beads trapping inside the microfluidics channel. The trapping is possible whenever the magnetic force is larger than the drag force experience by the magnetic microbead. The microfluidics channel with chamber design had facilitated low hydrodynamics drag force on the magnetic beads and resulted high efficiency trapping. Therefore, the development of this LoC magnetic separator may be promising to be utilized for biological studies and point-of-care testing (POCT) applications.

Item Type:Article
Uncontrolled Keywords:magnetic separator, microfluidics, trapping efficiency
Subjects:T Technology > TJ Mechanical engineering and machinery
Divisions:Mechanical Engineering
ID Code:88944
Deposited By: Narimah Nawil
Deposited On:29 Dec 2020 12:43
Last Modified:29 Dec 2020 12:43

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