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Electrospun combination of peppermint oil and copper sulphate with conducive physico-chemical properties for wound dressing applications

Jaganathan, Saravana Kumar and Mani, Mohan Prasath and Md. Khudzari, Ahmad Zahran (2019) Electrospun combination of peppermint oil and copper sulphate with conducive physico-chemical properties for wound dressing applications. Polymers, 11 (4). pp. 1-15. ISSN 2073-4360

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Official URL: http://dx.doi.org/10.3390/polym11040586

Abstract

The ultimate goal in tissue engineering is to fabricate a scaffold which could mimic the native tissue structure. In this work, the physicochemical and biocompatibility properties of electrospun composites based on polyurethane (PU) with added pepper mint (PM) oil and copper sulphate (CuSO4) were investigated. Field Emission Electron microscope (FESEM) study depicted the increase in mean fiber diameter for PU/PM and decrease in fiber diameter for PU/PM/CuSO4 compared to the pristine PU. Fourier transform infrared spectroscopy (FTIR) analysis revealed the formation of a hydrogen bond for the fabricated composites as identified by an alteration in PU peak intensity. Contact angle analysis presented the hydrophobic nature of pristine PU and PU/PM while the PU/PM/CuSO4 showed hydrophilic behavior. Atomic force microscopy (AFM) analysis revealed the increase in the surface roughness for the PU/PM while PU/PM/CuSO4 showed a decrease in surface roughness compared to the pristine PU. Blood compatibility studies showed improved blood clotting time and less toxic behavior for the developed composites than the pristine PU. Finally, the cell viability of the fabricated composite was higher than the pristine PU as indicated in the MTS assay. Hence, the fabricated wound dressing composite based on PU with added PM and CuSO4 rendered a better physicochemical and biocompatible nature, making it suitable for wound healing applications.

Item Type:Article
Uncontrolled Keywords:biocompatibility, physico-chemical properties
Subjects:T Technology > TP Chemical technology
Divisions:Biosciences and Medical Engineering
ID Code:88785
Deposited By: Yanti Mohd Shah
Deposited On:29 Dec 2020 04:25
Last Modified:29 Dec 2020 04:25

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