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The potential of biomimetic nanofibrous electrospun scaffold comprising dual component for bone tissue engineering

Jaganathan, Saravana Kumar and Mani, Mohan Prasath and Nageswaran, Gomathi and Krishnasamy, Navaneetha Pandiyaraj and Ayyar, Manikandan (2019) The potential of biomimetic nanofibrous electrospun scaffold comprising dual component for bone tissue engineering. International Journal of Polymer Analysis and Characterization, 24 (3). pp. 204-218. ISSN 1023-666X

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Official URL: http://dx.doi.org/10.1080/1023666X.2018.1564127


Oils play a putative choice for alleviating various symptoms associated with bone-related disorders. In this present study, polyurethane (PU) scaffold encompassing with Mahua oil (MO) and propolis (PP) were developed using the electrospinning technique. Morphological analysis showed the reduction in the diameter of the electrospun scaffold with blending of MO and MO/PP into the PU matrix. The strong interactions between PU, MO, and PP were evident through the infrared spectrum and thermal analysis. The wettability results showed the hydrophobic nature in electrospun PU/MO scaffold and hydrophilic behavior in electrospun PU/MO/PP scaffold. Mechanical testing indicated the enhancement in the strength of the PU due to the addition of MO and PP. Moreover, the fabricated scaffolds exhibited nontoxicity, low hemoglobin release and improved blood clotting time as evident in the coagulation studies. The cell proliferation studies showed the enhanced fibroblast cell adhesion in the developed nanocomposites than the pristine PU. Hence, the fabricated PU scaffolds blended with MO and PP having desirable properties can serve as a valuable candidate for bone tissue repair.

Item Type:Article
Uncontrolled Keywords:polyurethane, roughness, tensile strength
Subjects:Q Science > QH Natural history > QH301 Biology
T Technology > TP Chemical technology
Divisions:Biosciences and Medical Engineering
ID Code:88383
Deposited By: Yanti Mohd Shah
Deposited On:15 Dec 2020 08:02
Last Modified:15 Dec 2020 08:02

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