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Development of PMMA-Mon-CNT bone cement with superior mechanical properties and favorable biological properties for use in bone-defect treatment

Pahlevanzadeh, F. and Bakhsheshi-Rad, H. R. and Ismail, A. F. and Aziz, M. and Chen, X. B. (2019) Development of PMMA-Mon-CNT bone cement with superior mechanical properties and favorable biological properties for use in bone-defect treatment. Materials Letters, 240 . pp. 9-12. ISSN 0167-577X

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Official URL: http://dx.doi.org/10.1016/j.matlet.2018.12.049

Abstract

Treatment of bone defects requires materials or bone cement with superior mechanical properties and favorable biological properties, but this remains unachievable to date. To address this issue, the present study aimed to synthesize and characterize a novel poly(methyl methacrylate) (PMMA) bone cement containing monticellite (Mon) and carbon nanotubes (CNTs) for bone defect treatment. Considerably better mechanical properties were noted in the PMMA-Mon-CNT vs. PMMA and PMMA-Mon bone cements due to the unique resistance of CNTs to crack formation and propagation. Favorable bioactivity was also found in the bone cements containing Mon and CNTs, whereas the PMMA bone cement presented poor bioactivity. Specifically, the incorporation of Mon and CNTs into the PMMA matrix promoted the attachment of MG63 cells compared to the PMMA cement. Thus, the PMMA-Mon-CNT bone cements developed are good potential candidates for filling bone defects in orthopedic surgeries.

Item Type:Article
Uncontrolled Keywords:bioactivity, carbon nanotubes, mechanical properties
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:88280
Deposited By: Yanti Mohd Shah
Deposited On:15 Dec 2020 07:56
Last Modified:15 Dec 2020 07:56

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