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Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite

Wang, Jian and Zakaria, Nor Hidayah and Abd. Razak, Saiful Izwan and Abdul Kadir, Mohammed Rafiq and Mat Nayan, Nadirul Hasraf and Li, Yi and Mat Amin, Khairul Anuar (2019) Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite. Composite Interfaces, 26 (5). pp. 465-478. ISSN 0927-6440

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Official URL: http://dx.doi.org/10.1080/09276440.2018.1508266

Abstract

This work reports the surface modification of 3D printed PLA scaffold with chitosan and its hydroxyapatite (HA) forming capability. PLA scaffold was fabricated using a desktop 3D printer followed by the inclusion of chitosan on the surface via surface entrapment. Confocal laser scanning microscopy (CLSM) images showed existence of chitosan entrapment with depth of 24 μm. Immersion of the modified PLA scaffold in simulated body fluid resulted in formation of apatite layers on the surface. Plus the entrapment method does not induce any cytotoxic response towards human fibroblast cell. This method provides a facile approach of obtaining 3D printed scaffold with good bioactivity thus has potential in biomimetic and tissue engineering.

Item Type:Article
Uncontrolled Keywords:simulated body fluid, surface modification
Subjects:Q Science > QD Chemistry
T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:87699
Deposited By: Yanti Mohd Shah
Deposited On:30 Nov 2020 21:09
Last Modified:30 Nov 2020 21:09

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