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Antibacterial activity and in vivo wound healing evaluation of polycaprolactone-gelatin methacryloyl-cephalexin electrospun nanofibrous

Rad, H. R.Bakhsheshi and Ismail, A. F. and Aziz, M. and Akbari, M. and Hadisi, Z. and Daroonparvar, M. and Chen, X. B. (2019) Antibacterial activity and in vivo wound healing evaluation of polycaprolactone-gelatin methacryloyl-cephalexin electrospun nanofibrous. Materials Letters, 256 . p. 126618. ISSN 0167-577X

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Official URL: http://dx.doi.org/10.1016/j.matlet.2019.126618

Abstract

Infections, particularly those induced via drug resistant pathogens, can cause serious issues in wound healing process. In this study, cephalexin (CEX), as an effective antibiotic, was loaded into polycaprolactone (PCL)-gelatin methacryloyl (GelMA) nanofibrous by electrospinning for the development of a new wound dressing. The electrospun nanofibrous possessed continuous and smooth structure with the fiber diameters ranging from 280 to 330 nm. Swelling examination exhibited that the electrospun nanofibrous could take up water by 400–600%. Antibacterial activity of PCL/GelMA loading with CEX had a great inhibition towards both Gram-positive Staphylococcus aureus and negative-bacteria Escherichia coli. The hematoxylin-eosin (H&E) and Masson's trichrome (MT) staining results from treated wounds with PCL/GelMA-CEX nanofibrous exhibited improved re-epithelialization and collagen deposition. Taken together, our study illustrate the PCL/GelMA-CEX nanofibrous can be promising for use as an effective antibacterial wound dressing in skin regeneration.

Item Type:Article
Uncontrolled Keywords:Antibacterial activity, Biomaterials
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:87694
Deposited By: Widya Wahid
Deposited On:30 Nov 2020 21:08
Last Modified:30 Nov 2020 21:08

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