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Solid-phase microextraction based on an agarose-chitosan-multiwalled carbon nanotube composite film combined with HPLC-UV for the determination of nonsteroidal anti-inflammatory drugs in aqueous samples

Wan Ibrahim, Wan Nazihah and Sanagi, Mohd. Marsin and Mohamad Hanapi, Nor Suhaila and Kamaruzaman, Sazlinda and Yahaya, Noorfatimah and Wan Ibrahim, Wan Aini (2018) Solid-phase microextraction based on an agarose-chitosan-multiwalled carbon nanotube composite film combined with HPLC-UV for the determination of nonsteroidal anti-inflammatory drugs in aqueous samples. Journal of Separation Science, 41 (14). pp. 2942-2951. ISSN 1615-9306

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Official URL: http://dx.doi.org/10.1002/jssc.201800064

Abstract

We describe the preparation, characterization, and application of a composite film adsorbent based on blended agarose-chitosan-multiwalled carbon nanotubes for the preconcentration of selected nonsteroidal anti-inflammatory drugs in aqueous samples before determination by high performance liquid chromatography with ultraviolet detection. The composite film showed a high surface area (4.0258 m2/g) and strong hydrogen bonding between the multiwalled carbon nanotubes and agarose/chitosan matrix, which prevent adsorbent deactivation and ensure long-term stability. Several parameters, such as sample pH, addition of salt, extraction time, desorption solvent, and concentration of multiwalled carbon nanotubes in the composite film were optimized using a one-factor-at-time approach. The optimum extraction conditions obtained were as follows: isopropanol as conditioning solvent, 10 mL of sample solution at pH 2, extraction time of 30 min, stirring speed of 600 rpm, 100 μL of isopropanol as desorption solvent, desorption time of 5 min under ultrasonication, and 0.4% w/v of composite film. Under the optimized conditions, the calibration curve showed good linearity in the range of 1–500 ng/mL (r2 = 0.997–0.999), and good limits of detection (0.89–8.05 ng/mL) were obtained with good relative standard deviations of < 4.59% (n = 3) for the determination of naproxen, diclofenac sodium salt, and mefenamic acid drugs.

Item Type:Article
Uncontrolled Keywords:blended agarose/chitosan, composite adsorbents, multiwalled carbon nanotubes, nonsteroidal anti-inflammatory drugs, solid-phase microextraction
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:85488
Deposited By: Yanti Mohd Shah
Deposited On:30 Jun 2020 16:56
Last Modified:30 Jun 2020 16:56

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