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Fabrication of gelatin scaffolds using thermally induced phase separation technique

Sultana, Naznin and Hassan, Mohd. Izzat and Ridzuan, Nursyazana and Ibrahim, Zaharah and Soon, Chin Fhong (2018) Fabrication of gelatin scaffolds using thermally induced phase separation technique. International Journal of Engineering, Transactions B: Applications, 31 (8). pp. 1302-1307. ISSN 1728-144X

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Official URL: http://www.ije.ir/article_73248.html

Abstract

Gelatin is considered as a partially degraded product of collagen and it is a biodegradable polymer which can be used to produce scaffolds for tissue engineering. Three-dimensional, porous gelatin scaffolds were fabricated by thermally induced phase separation and freeze-drying method. Their porous structure and pore size were characterized by scanning electron microscopy. Scaffolds with different pore sizes were obtained by adjusting the concentration of the gelatin solution. Scaffolds with 3.75% (w/v) gelatin and 5% (w/v) gelatin produced pores ranging from 100 to 450µm. The average pore size increased with an increase in gelatin concentration. The properties of the scaffolds in terms of water uptake were studied. The results showed that when the concentration of the gelatin solution was changed from 3.75% to 5%, the water absorption of the fabricated scaffolds decreased by 104%. The increment in the concentration of gelatin induced a reduction in water uptake in the scaffolds produced. © 2018 Materials and Energy Research Center.

Item Type:Article
Uncontrolled Keywords:gelatin, polymer concentration, scaffolds, scanning electron microscope, thermally induced phase separation
Subjects:Q Science > QH Natural history > QH301 Biology
T Technology > TA Engineering (General). Civil engineering (General)
Divisions:Biosciences and Medical Engineering
ID Code:84745
Deposited By: Yanti Mohd Shah
Deposited On:27 Feb 2020 12:53
Last Modified:27 Feb 2020 12:53

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