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Drug discovery - yesterday and tomorrow: the common approaches in drug design and cancer

Amran, Syazwani Itri (2018) Drug discovery - yesterday and tomorrow: the common approaches in drug design and cancer. Cell & Cellular Life Sciences Journal, 3 (1). pp. 1-10.

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Official URL: http://dx.doi.org/10.23880/CCLSJ-16000119

Abstract

The process of drug discovery has undergone radical changes and development over years. Traditionally, the drugs were discovered by employing chemistry and pharmacology - based cautious approach. When natural products were the most important source of drugs or drug precursors, but the conventional randomized drug research phenomenon was no longer effective at that time due to many negatives of these approaches like: high expenses of discovering new drugs, time - consuming and reduced success guarantee. Thus, with the development of the era, the concept of “Rational Drug Design” has enabled drug target identification and validation to be more specific. In addition, several novel technologies and approaches have been introducing economics, proteomics and other omics areas such as 3D QSAR, pharmacophore modeling and other, which playing a promising role in accelerating the pace of drug discovery process. Their view of the current research focuses on the importance of drug discovery in modern times and shows how old methods have been replaced and summarized. Some of examples of molecules are identified in addition to computational approaches used to discover it, specifically in the field of anticancer drug design.

Item Type:Article
Uncontrolled Keywords:drug discovery, drug design
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:82220
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:30 Sep 2019 17:00
Last Modified:11 Nov 2019 09:22

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