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Screening of thymoquinone (TQ) content in Nigella sativa-based herbal medical products

Amran, Syazwani Itri and Ahmad Muhamud, Nurul Ain Syukriyah and Mohamad, Nurulain Syamimi (2018) Screening of thymoquinone (TQ) content in Nigella sativa-based herbal medical products. Journal of Natural Product and Plant Resources, 8 (3). pp. 41-45. ISSN 2231-3184

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Abstract

Nigella sativa seed contains a bioactive compound known as thymoquinone (TQ) which is prominent for its pharmacological properties such as antioxidant; anti-microbial, antibacterial and anti-inflammatory hence, becomes an important ingredient in Herbal Medicinal Products (HMPs). However, adulteration of HMPs has raised concerns among consumers. This study aims to extract and characterize TQ from Nigella sativa based products. TQ was isolated from raw Nigella sativa seeds using methanolic and aqueous extraction methods. Extracts were subject to qualitative and quantitative analysis using High-Performance Liquid chromatography (HPLC). Both extraction methods produced TQ extracts with methanol extraction yielded 63.4 µg/mL while aqueous extraction method produced 15.3 µg/mL. Quantitative analysis of 13 commercialized products containing Nigella sativa such as oil, capsule, facial foam, shower foam, and toothpaste showed presence of TQ at varying concentration. The effectiveness of TQ exhibits its pharmacological activity is questionable because the concentration of TQ in the product was not stated on the packaging.

Item Type:Article
Uncontrolled Keywords:herbal medical products
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:82156
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:30 Sep 2019 17:00
Last Modified:06 Nov 2019 09:37

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