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Molecular basis and engineering of enzymes stereospecificity

Adamu, Aliyu and Aliyu, Firdausi and Huyop, Fahrul Zaman and Abdul Wahab, Roswanira (2018) Molecular basis and engineering of enzymes stereospecificity. Journal Of Molecular Biology And Methods, 1 (1). pp. 1-7.

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Official URL: https://www.scitechnol.com/peer-review/molecular-b...

Abstract

Molecular recognition, particularly enantiomeric specificity of biological molecules is a key consideration in designing drugs, pharmaceutical intermediate and in industrial production of chirally active intermediate. Although the molecular bases of many enzymes stereospecificity are not completely delineated, a number of protein engineering studies were able to enhance and even in some cases invert the stereospecificity of various enzymes. Herein, we review the current understanding on enzymes stereospecificity, and the effects of mutations to the stereospecific pockets due to enzymes engineering to improve stereospecificity.

Item Type:Article
Uncontrolled Keywords:molecular basis, stereospecificity, enzymes, protein engineering
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Biosciences and Medical Engineering
ID Code:81972
Deposited By: Yanti Mohd Shah
Deposited On:30 Sep 2019 17:00
Last Modified:08 Oct 2019 09:46

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