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Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives

Mienda, Bashir Sajo and Mohd. Salleh, Faezah (2017) Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives. AIMS Bioengineering, 4 (4). pp. 418-430. ISSN 2375-1495


Official URL: https://dx.doi.org/10.3934/bioeng.2017.4.418


Escherichia coli (E. coli) has been established to be a native producer of succinic acid (a platform chemical with different applications) via mixed acid fermentation reactions. Genome-scale metabolic models (GEMs) of E. coli have been published with capabilities of predicting strain design strategies for the production of bio-based succinic acid. Proof-of-principle strains are fundamentally constructed as a starting point for systems strategies for industrial strains development. Here, we review for the first time, the use of E. coli GEMs for construction of proof-of-principles strains for increasing succinic acid production. Specific case studies, where E. coli proof-of-principle strains were constructed for increasing bio-based succinic acid production from glucose and glycerol carbon sources have been highlighted. In addition, a propose systems strategies for industrial strain development that could be applicable for future microbial succinic acid production guided by GEMs have been presented.

Item Type:Article
Uncontrolled Keywords:bio-succinic acid production, Escherichia coli strain design, genome-scale metabolic models, proof-of-principle strains
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Biosciences and Medical Engineering
ID Code:80777
Deposited By: Fazli Masari
Deposited On:27 Jun 2019 06:24
Last Modified:27 Jun 2019 06:24

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