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UV induced surface modification on improving the cytocompatibility of metallocene polyethylene

Jaganathan, S. K. and Prasath, M. M. (2018) UV induced surface modification on improving the cytocompatibility of metallocene polyethylene. Anais da Academia Brasileira de Ciencias, 90 (1). pp. 195-204. ISSN 0001-3765

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Official URL: http://dx.doi.org/10.1590/0001-3765201820170736

Abstract

Demand for medical implants is rising day by day as the world becomes the place for more diseased and older people. Accordingly, in this research, metallocene polyethylene (mPE), a commonly used polymer was treated with UV rays for improving its biocompatibility. Scanning electron microscopy (SEM) images confirmed the formation of crests and troughs, which depicts the improvement of surface roughness of mPE substrates caused by UV etching. Accordingly, the contact angle measurements revealed that the wettability of mPE-2.5 J/cm2 (68.09º) and mPE-5 J/cm2 (57.93º) samples were found to be increased compared to untreated mPE (86.84º) indicating better hydrophilicity. Further, the UV treated surface exhibited enhanced blood compatibility as determined in APTT (untreated mPE- 55.3 ± 2.5 s, mPE-2.5 J/ cm2 - 76.7 ± 4.1 s and mPE-5 J/cm2 - 112.3 ± 2 s) and PT (untreated mPE - 24.7 ± 1.5 s, mPE- 2.5 J/cm2 - 34.3 ± 1.1 s and mPE-5 J/cm2 - 43 ± 2 s) assay. Moreover, the treated mPE-2.5 J/cm2 (4.88%) and mPE-5 J/cm2 (1.79%) showed decreased hemolytic percentage compared to untreated mPE (15.40%) indicating better safety to red blood cells. Interestingly, the changes in physicochemical properties of mPE are directly proportional to the dosage of the UV rays. UV modified mPE surfaces were found to be more compatible as identified through MTT assay, photomicrograph and SEM images of the seeded 3T3 cell population. Hence UV-modified surface of mPE may be successfully exploited for medical implants.

Item Type:Article
Uncontrolled Keywords:Biocompatible polymers, Blood compatibility, Cytotoxicity properties, Metallocene polyethylene, Surface properties, UV treatment
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:79941
Deposited By: Narimah Nawil
Deposited On:28 Jan 2019 15:02
Last Modified:28 Jan 2019 15:02

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