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Fabrication of poly(lactic-co-glycolic acid)/calcium phosphate bone cement composite: synthesization of calcium phosphate from crab shells

Abdul Hanan, M. R. and Nasution, A. K. and Hussain, R. and Saidin, S. (2018) Fabrication of poly(lactic-co-glycolic acid)/calcium phosphate bone cement composite: synthesization of calcium phosphate from crab shells. Jurnal Teknologi, 80 (4). pp. 103-109. ISSN 0127-9696

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Official URL: http://dx.doi.org/10.11113/jt.v80.11525

Abstract

Crab shells are waste product, rich with calcium compound. Calcium element is often used as a material for bone scaffold due to its bioactive and biodegradation properties. In this study, calcium phosphate (CaP) nanoparticles were synthesized from crab shells through a wet chemical route. The CaP nanoparticles were then sintered and mixed with poly(lactic-co-glycolic acid) (PLGA) to form a bone cement composite. The mixture was casted in a cylinder shape and it was characterized through ATR-FTIR, XRD, FESEM, contact angle and DSC analyses. The CaP pellet and the CaP/PLGA bone cement composite were then subjected to in vitro simulated body fluid (SBF) bioactivity test. The CaP/PLGA bone cement composite was found to have a composition of crystal CaP and PLGA with a tolerable glass transition state, suitable to be used in a physiological environment. The CaP nanoparticles were agglomerated on the 3D interconnected surface of PLGA. The hydrophobicity of the CaP was increased (66.94%) with the addition of PLGA as a binder matrix where this composite has induced the formation of apatite layer. This bioactive property is crucial in fabricating a bone substitute material as it can promotes cell penetration, attachment and proliferation.

Item Type:Article
Uncontrolled Keywords:Bioactive, Bone cement, Calcium phosphate, Crab shells, Poly(lactic-co-glycolic acid)
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Biosciences and Medical Engineering
ID Code:79704
Deposited By: Fazli Masari
Deposited On:28 Jan 2019 14:38
Last Modified:28 Jan 2019 14:38

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