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Surface, thermal and hemocompatible properties of novel single stage electrospun nanocomposites comprising polyurethane blended with bio oil (TM)

Ayyar, Manikandan and Mani, Mohan Prasath and Jaganathan, Saravana Kumar and Rathinasamy, Rajasekar and Khudzari, Ahmad Zahran and Krishnasamy, Navaneetha Pandiyaraj (2017) Surface, thermal and hemocompatible properties of novel single stage electrospun nanocomposites comprising polyurethane blended with bio oil (TM). Anais da Academia Brasileira de Ciencias, 89 (3). pp. 2411-2422. ISSN 0001-3765

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Abstract

In this work, the physicochemical and blood compatibility properties of prepared PU/Bio oil nanocomposites were investigated. Scanning electron microscope (SEM) studies revealed the reduction of mean fiber diameter (709 ± 211 nm) compared to the pristine PU (969 nm ± 217 nm). Fourier transform infrared spectroscopy (FTIR) analysis exposed the characteristic peaks of pristine PU. Composite peak intensities were decreased insinuating the interaction of the bio oil™ with the PU. Contact angle analysis portrayed the hydrophobic nature of the fabricated patch compared to pristine PU. Thermal gravimetric analysis (TGA) depicted the better thermal stability of the novel nanocomposite patch and its different thermal behavior in contrast with the pristine PU. Atomic force microscopy (AFM) analysis revealed the increase in the surface roughness of the composite patch. Activated partial thromboplastin time (APTT) and prothrombin time (PT) signified the novel nanocomposite patch ability in reducing the thrombogenicity and promoting the anticoagulant nature. Finally the hemolytic percentage of the fabricated composite was in the acceptable range revealing its safety and compatibility with the red blood cells. To reinstate, the fabricated patch renders promising physicochemical and blood compatible nature making it a new putative candidate for wound healing application.

Item Type:Article
Uncontrolled Keywords:Polyurethane, Bio oil (TM), Nanocomposite, atomic force microscopy, wound healing
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:77508
Deposited By: Widya Wahid
Deposited On:24 Sep 2018 09:22
Last Modified:24 Sep 2018 09:22

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