Universiti Teknologi Malaysia Institutional Repository

NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats

Xu, Jingjing and Zheng, Xujuan and Cheng, Kian Kai and Chang, Xiaorong and Shen, Guiping and Liu, Mi and Wang, Yadong and Shen, Jiacheng and Zhang, Yuan and He, Qida and Dong, Jiyang and Yang, Zongbao (2017) NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats. Scientific Reports, 7 (45580). pp. 1-12. ISSN 2045-2322

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Official URL: https://www.nature.com/articles/srep45580.pdf

Abstract

Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet to be established. In the present study, an integrated histopathological examination along with molecular biological assay, as well as 1H NMR analysis of multiple biological samples (urine, serum, stomach, cortex and medulla) were employed to systematically assess the pathology of CAG and therapeutic effect of electro-acupuncture stimulation at Sibai (ST 2), Liangmen (ST 21), and Zusanli (ST 36) acupoints located in the stomach meridian using a rat model of CAG. The current results showed that CAG caused comprehensive metabolic alterations including the TCA cycle, glycolysis, membrane metabolism and catabolism, gut microbiota-related metabolism. On the other hand, electro-acupuncture treatment was found able to normalize a number of CAG-induced metabolomics changes by alleviating membrane catabolism, restoring function of neurotransmitter in brain and partially reverse the CAG-induced perturbation in gut microbiota metabolism. These findings provided new insights into the biochemistry of CAG and mechanism of the therapeutic effect of electro-acupuncture stimulations.

Item Type:Article
Uncontrolled Keywords:Chronic atrophic gastritis (CAG), gastrointestinal disease
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:77431
Deposited By: Widya Wahid
Deposited On:30 Jun 2018 06:25
Last Modified:30 Jun 2018 06:25

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