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Development of biocompatible and safe polyethersulfone hemodialysis membrane incorporated with functionalized multi-walled carbon nanotubes

Abidin, M. N. Z. and Goh, P. S. and Ismail, A. F. and Othman, M. H. D. and Hasbullah, H. and Said, N. and Kadir, S. H. S. A. and Kamal, F. and Abdullah, M. S. and Ng, B. C. (2017) Development of biocompatible and safe polyethersulfone hemodialysis membrane incorporated with functionalized multi-walled carbon nanotubes. Materials Science and Engineering C, 77 . pp. 572-582. ISSN 0928-4931

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Abstract

A novel approach in the design of a safe, high performance hemodialysis membrane is of great demand. Despite many advantages, the employment of prodigious nanomaterials in hemodialysis membrane is often restricted by their potential threat to health. Hence, this work focusses on designing a biocompatible polyethersulfone (PES) hemodialysis membrane embedded with poly (citric acid)-grafted-multi walled carbon nanotubes (PCA-g-MWCNTs). Two important elements which could assure the safety of the nanocomposite membrane, i.e. (i) dispersion stability and (ii) leaching of MWCNTs were observed. The results showed the improved dispersion stability of MWCNTs in water and organic solvent due to the enriched ratio of oxygen-rich groups which subsequently enhanced membrane separation features. It was revealed that only 0.17% of MWCNTs was leached out during the membrane fabrication process (phase inversion) while no leaching was detected during permeation. In terms of biocompatibility, PES/PCA-g-MWCNT nanocomposite membrane exhibited lesser C3 and C5 activation (189.13 and 5.29 ng/mL) and proteins adsorption (bovine serum albumin = 4.5 μg/cm2, fibrinogen = 15.95 μg/cm2) as compared to the neat PES membrane, while keeping a normal blood coagulation time. Hence, the PES/PCA-g-MWCNT nanocomposite membrane is proven to have the prospect of becoming a safe and high performance hemodialysis membrane.

Item Type:Article
Uncontrolled Keywords:Hemodialysis membrane, Leaching phenomenon
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:76933
Deposited By: Fazli Masari
Deposited On:31 May 2018 17:31
Last Modified:31 May 2018 17:31

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