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Drug delivery and cytocompatibility of ciprofloxacin loaded gelatin nanofibers-coated Mg alloy

Bakhsheshi-Rad, H. R. and Hadisi, Z. and Hamzah, E. and Ismail, A. F. and Aziz, M. and Kashefian, M. (2017) Drug delivery and cytocompatibility of ciprofloxacin loaded gelatin nanofibers-coated Mg alloy. Materials Letters, 207 . pp. 179-182. ISSN 0167-577X

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Abstract

In this study, gelatin-ciprofloxacin (Gel-Cip) nanofibers containing various amounts of Cip (0, 2, 4 and, 8 wt%) were fabricated on the surface of Mg-1Ca alloy via an electrospinning process. Microscopic characterization indicated a porous network structure with fiber diameters in the range of 150–170 nm. Prolonged drug release was attained from Gel-Cip nanofibers coating along with initial rapid drug release of around 20–22% during 12 h, followed by a slow release stage that can effectively control the infection. The incorporation of 2–4 wt% Cip into Gel nanofibers coating significantly increased the antibacterial performance and corrosion resistance of the uncoated Mg-Ca alloy without showing an inhibitory influence on the cytocompatibility characteristic. Hence, it is potentially appropriate as the novel electrospun nanofibers coating material for bone regeneration application.

Item Type:Article
Uncontrolled Keywords:Electrospinning, Gelatin nanofibers
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:76925
Deposited By: Fazli Masari
Deposited On:31 May 2018 17:31
Last Modified:31 May 2018 17:31

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