Universiti Teknologi Malaysia Institutional Repository

Novel nanostructured baghdadite-vancomycin scaffolds: in-vitro drug release, antibacterial activity and biocompatibility

Bakhsheshi-Rad, H. R. and Hamzah, E. and Ismail, A. F. and Aziz, M. and Hadisi, Z. and Kashefian, M. and Najafinezhad, A. (2017) Novel nanostructured baghdadite-vancomycin scaffolds: in-vitro drug release, antibacterial activity and biocompatibility. Materials Letters, 209 . pp. 369-372. ISSN 0167-577X

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

One of the most important therapeutic and economic concerns regarding surgery, is the occurrence of post-operative infections which leads to an increase in premature failure rate. Therefore, novel nanostructured baghdadite-vancomycin (Ba-Vac) scaffolds were prepared using the space holder method with good mechanical properties and controlled drug release to inhibit post-surgery infections. The results showed that the (Ba-Vac) scaffolds were attained with the pore size of 300–400 µm and total porosity of 80–82% with compressive strength of 0.86–0.88 MPa. In drug release profiles, a burst release was observed for 6 h, followed by a sustained release. Ba-Vac scaffolds presented good antibacterial activity toward Staphylococcus aureus (S. aureus). More attachment and spreading of MG-63 osteoblast cells on the Ba and Ba-(1-3 wt%)Vac scaffolds was also observed in comparison with the Ba-5 wt%Vac scaffold. Therefore, the Ba-(1–3 wt%)Vac scaffold is a good candidate for inhibiting post-surgery infections, as well as for bone tissue engineering.

Item Type:Article
Uncontrolled Keywords:Drug release, Vancomycin
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:76924
Deposited By: Fazli Masari
Deposited On:31 May 2018 17:31
Last Modified:31 May 2018 17:31

Repository Staff Only: item control page