Universiti Teknologi Malaysia Institutional Repository

Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold

Lim, M. M. and Sultana, N. (2017) Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold. Malaysian Journal of Analytical Sciences, 21 (3). pp. 627-632. ISSN 1394-2506

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Tissue engineering has emerged to provide a new medical therapy in helping tissue regrowth and regeneration by employing scaffold as an artificial supporting structure for cellular growth. Many polymers have been utilized in the fabrication of these artificial scaffolds, but there is still a need to fabricate hydrophilic nanofibrous scaffold with appropriate degradation rate. In this study, polycaprolactone (PCL) and polycaprolactone/gelatin (PCL/Ge) 70:30 nanofibrous scaffolds were fabricated using electrospinning technique and compared on in vitro degradation rate to determine a more suitable scaffold for skin tissue engineering application. In vitro degradation was evaluated by morphological changes, water uptake, and chemical bonding until 12 weeks. Result shows that both PCL and PCL/Ge (70:30) nanofibrous scaffolds were degraded after 8th week. However, the degradation rate of PCL nanofibrous scaffold is slower and does not has obvious morphological changes. PCL/Ge (70:30) nanofibrous scaffold with faster degradation rate have the potential for skin tissue engineering application.

Item Type:Article
Uncontrolled Keywords:Polycaprolactone/gelatine, Tissue engineering
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:76820
Deposited By: Fazli Masari
Deposited On:30 Apr 2018 22:10
Last Modified:30 Apr 2018 22:10

Repository Staff Only: item control page