Universiti Teknologi Malaysia Institutional Repository

Magnetic micro-solid-phase extraction based on magnetite-MCM-41 with gas chromatography–mass spectrometry for the determination of antidepressant drugs in biological fluids

Kamaruzaman, S. and Sanagi, M. M. and Yahaya, N. and Wan Ibrahim, W. A. and Endud, S. and Wan Ibrahim, W. N. (2017) Magnetic micro-solid-phase extraction based on magnetite-MCM-41 with gas chromatography–mass spectrometry for the determination of antidepressant drugs in biological fluids. Journal of Separation Science, 40 (21). pp. 4222-4233. ISSN 1615-9306

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

A new facile magnetic micro-solid-phase extraction coupled to gas chromatography and mass spectrometry detection was developed for the extraction and determination of selected antidepressant drugs in biological fluids using magnetite-MCM-41 as adsorbent. The synthesized sorbent was characterized by several spectroscopic techniques. The maximum extraction efficiency for extraction of 500 μg/L antidepressant drugs from aqueous solution was obtained with 15 mg of magnetite-MCM-41 at pH 12. The analyte was desorbed using 100 μL of acetonitrile prior to gas chromatography determination. This method was rapid in which the adsorption procedure was completed in 60 s. Under the optimized conditions using 15 mL of antidepressant drugs sample, the calibration curve showed good linearity in the range of 0.05–500 μg/L (r2 = 0.996–0.999). Good limits of detection (0.008–0.010 μg/L) were obtained for the analytes with good relative standard deviations of <8.0% (n = 5) for the determination of 0.1, 5.0, and 500.0 μg/L of antidepressant drugs. This method was successfully applied to the determination of amitriptyline and chlorpromazine in plasma and urine samples. The recoveries of spiked plasma and urine samples were in the range of 86.1–115.4%. Results indicate that magnetite micro-solid-phase extraction with gas chromatography and mass spectrometry is a convenient, fast, and economical method for the extraction and determination of amitriptyline and chlorpromazine in biological samples.

Item Type:Article
Uncontrolled Keywords:magnetic micro-solid-phase extraction, magnetite
Subjects:Q Science > QC Physics
Divisions:Science
ID Code:76546
Deposited By: Fazli Masari
Deposited On:30 Apr 2018 21:30
Last Modified:30 Apr 2018 21:30

Repository Staff Only: item control page