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Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes

Zailani, M. Z. and Ismail, A. F. and Sheikh Abdul Kadir, S. H. and Othman, M. H. D. and Goh, P. S. and Hasbullah, H. and Abdullah, M. S. and Ng, B. C. and Kamal, F. (2017) Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes. Journal of Biomedical Materials Research - Part A, 105 (5). pp. 1510-1520. ISSN 1549-3296

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In this study, poly (1,8-octanediol citrate) (POC) was used to modify polyethersulfone (PES)-based membrane to enhance its hemocompatibility. Different compositions of POC (0–3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection. The hemocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), and thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+ absorption on membrane. Results showed that by increasing POC concentration, FBG adsorption was reduced, less platelets adhesion, prolonged APTT and PT, lower TAT, C5a and C3a activation and absorb more Ca2+ ion. These results indicated that modification of PES with POC has rendered improved hemocompatibility properties for potential application in the field of blood purification, especially in hemodialysis.

Item Type:Article
Uncontrolled Keywords:hemocompatible, hemodialysis membrane
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Biosciences and Medical Engineering
ID Code:76435
Deposited By: Fazli Masari
Deposited On:30 Apr 2018 13:23
Last Modified:30 Apr 2018 13:23

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