Universiti Teknologi Malaysia Institutional Repository

Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria

Saarani, N. N. and Jamuna Thevi, K. and Shahab, N. and Hermawan, H. and Saidin, S. (2017) Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria. Dental Materials Journal, 36 (3). pp. 260-265. ISSN 0287-4547

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

A guided bone regeneration (GBR) membrane has been extensively used in the repair and regeneration of damaged periodontal tissues. One of the main challenges of GBR restoration is bacterial colonization on the membrane, constitutes to premature membrane degradation. Therefore, the purpose of this study was to investigate the antibacterial efficacy of triple-layered GBR membrane composed of poly(lactic-co-glycolic acid) (PLGA), nanoapatite (NAp) and lauric acid (LA) with two types of Gram-negative periodontal bacteria, Fusobacterium nucleatum and Porphyromonas gingivalis through a disc diffusion and bacterial count tests. The membranes exhibited a pattern of growth inhibition and killing effect against both bacteria. The increase in LA concentration tended to increase the bactericidal activities which indicated by higher diameter of inhibition zone and higher antibacterial percentage. It is shown that the incorporation of LA into the GBR membrane has retarded the growth and proliferation of Gram-negative periodontal bacteria for the treatment of periodontal disease.

Item Type:Article
Uncontrolled Keywords:guided bone regeneration (GBR), bacterial colonization
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:76080
Deposited By: Widya Wahid
Deposited On:30 May 2018 12:19
Last Modified:30 May 2018 12:19

Repository Staff Only: item control page