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Development of Diabecine™ tablet and confirmation of its physical properties and pharmaceutical safety analysis

Teh, Liam Chee and Abdul Majid, Fadzilah Adibah and Mohd. Amin, Mohd. Cairul Iqbal (2017) Development of Diabecine™ tablet and confirmation of its physical properties and pharmaceutical safety analysis. Sains Malaysiana, 46 (4). pp. 597-604. ISSN 0126-6039

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Official URL: http://dx.doi.org/10.17576/jsm-2017-4604-12

Abstract

Herbal medicine is usually made using dry powdered herbs in the form of capsule. Capsule form herbal supplement suffers lower shelf life as compared to compact herbal powder in tablet form. In this study, Diabecine™, a blend of herbal medicine traditionally used as herbal supplement for diabetic patients was selected and transformed into a compressed tablet. Direct compression method and minimal usage of excipients were the aims of this study. By using direct compression, the blend of 40% fine powder herbs and 60% of excipients performed the best and fulfill the pharmaceutical standard. The safety data of microbial and heavy metal testing obtained met the safety requirements for herbal supplement category under the National Pharmaceutical Control Bureau of Malaysia. In conclusion, the tablet formulation of Diabecine™ is suitable to be manufactured by using direct compression method. This research implicates the possibility of producing tablets with high dose of herbal powder by direct compression method.

Item Type:Article
Uncontrolled Keywords:Direct compression, FTIR, herbal supplement, impurity, tablet characteristic
Subjects:T Technology > TA Engineering (General). Civil engineering (General)
Divisions:Chemical Engineering
ID Code:75751
Deposited By: Yanti Mohd Shah
Deposited On:30 Apr 2018 21:15
Last Modified:12 Nov 2018 16:01

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