Universiti Teknologi Malaysia Institutional Repository

1H NMR-based investigation of metabolic response to electro-acupuncture stimulation

Lin, C. and Wei, Z. and Cheng, K. K. and Xu, J. and Shen, G. and She, C. and Zhong, H. and Chang, X. and Dong, J. (2017) 1H NMR-based investigation of metabolic response to electro-acupuncture stimulation. Scientific Reports, 7 (1). ISSN 2045-2322


Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....


Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance (1H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats. 1H-NMR spectra datasets of serum, urine, cortex, and stomach tissue extracts from the rats were analysed by multivariate statistical analysis to investigate metabolic perturbations due to EA treatments at different meridians. EA treatment on either the SMFY or GMFS acupoints induced significant variations in 31 metabolites, e.g., amino acids, organic acids, choline esters and glucose. Moreover, a few meridian-specific metabolic changes were found for EA stimulations on the SMFY or GMFS acupoints. Our study demonstrated significant metabolic differences in response to EA stimulations on acupoints of SMFY and GMFS meridians. These results validate the hypothesis that meridian specificity in acupuncture is detectable in the metabolome and demonstrate the feasibility and effectiveness of a metabolomics approach in understanding the mechanism of acupuncture.

Item Type:Article
Uncontrolled Keywords:stomach meridian of foot-yangming (SMFY), electro-acupuncture (EA)
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Biosciences and Medical Engineering
ID Code:74844
Deposited By: Fazli Masari
Deposited On:21 Mar 2018 00:22
Last Modified:21 Mar 2018 00:22

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