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Metabolomics, lipidomics and pharmacometabolomics of human hypertension

Au, A. and Cheng, K. K. and Wei, L. K. (2017) Metabolomics, lipidomics and pharmacometabolomics of human hypertension. In: Advances in Experimental Medicine and Biology. Springer New York LLC, pp. 599-613.

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Abstract

Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular mechanism of hypertension. Although there have been limited metabolomic, lipidomic and pharmacometabolomic studies investigating this disease to date, metabolomic studies on hypertension have provided greater insights into the identification of disease-specific biomarkers, predicting treatment outcome and monitor drug safety and efficacy. Therefore, we discuss recent updates on the applications of metabolomics technology in human hypertension with a focus on metabolic biomarker discovery.

Item Type:Book Section
Uncontrolled Keywords:Hypertension, Lipidomics, Metabolomics, Pharmacometabolomics
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:74819
Deposited By: Fazli Masari
Deposited On:28 Nov 2017 16:38
Last Modified:28 Nov 2017 16:38

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