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PEDOT:PSS-containing nanohydroxyapatite/chitosan conductive bionanocomposite scaffold: fabrication and evaluation

Lari, Alireza and Sun, Tao and Sultana, Naznin (2016) PEDOT:PSS-containing nanohydroxyapatite/chitosan conductive bionanocomposite scaffold: fabrication and evaluation. Journal of Nanomaterials, 2016 . ISSN 1687-4110

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Abstract

Conductive poly(3,4-ethylenedioxythiophene)-poly(4-styrene sulfonate) (PEDOT:PSS) was incorporated into nanohydroxyapatite/chitosan (nHA/CS) composite scaffolds through a freezing and lyophilization technique. The bionanocomposite conductive scaffold was then characterized using several techniques. A scanning electron microscope image showed that the nHA and PEDOT:PSS were dispersed homogeneously in the chitosan matrix, which was also confirmed by energy-dispersive X-ray (EDX) analysis. The conductive properties were measured using a digital multimeter. The weight loss and water-uptake properties of the bionanocomposite scaffolds were studied in vitro. An in vitro cell cytotoxicity test was carried out using mouse fibroblast (L929) cells cultured onto the scaffolds. Using a freezing and lyophilization technique, it was possible to fabricate three-dimensional, highly porous, and interconnected PEDOT:PSS/nHA/CS scaffolds with good handling properties. The porosity was 74% and the scaffold's conductivity was 9.72 ± 0.78 μS. The surface roughness was increased with the incorporation of nHA and PEDOT:PSS into the CS scaffold. The compressive mechanical properties increased significantly with the incorporation of nHA but did not change significantly with the incorporation of PEDOT:PSS. The PEDOT:PSS-containing nHA/CS scaffold exhibited significantly higher cell attachment. The PEDOT:PSS/nHA/CS scaffold could be a potential bionanocomposite conductive scaffold for tissue engineering.

Item Type:Article
Uncontrolled Keywords:Biomechanics, Cell culture, Freezing, Scaffolds (biology), Scanning electron microscopy, Surface roughness, Tissue engineering, Composite scaffolds, Compressive mechanical properties, Conductive properties, Digital multimeters, Energy dispersive x-ray, Nano-hydroxyapatite, Poly-3 ,4-ethylenedioxythiophene, Water uptake properties, Conducting polymers
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:74626
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:30 Nov 2017 07:58
Last Modified:30 Nov 2017 07:58

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