Siam, F. M. and Grinfeld, M. (2016) A structurally unstable bistable system. In: 23rd Malaysian National Symposium of Mathematical Sciences: Advances in Industrial and Applied Mathematics, SKSM 2015, 24 November 2015 through 26 November 2015, Johor Bahru; Malaysia.
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Abstract
Bistability (or more generally multistability, the coexistence of two or more stable steady states in a dynamical system) is an important property of many dynamical systems in biology. It furnishes an explanation for the ability of isogenic cells to present different stable expression profiles. In this work, we show analytically that the Cdc2-cyclin B/Wee1 system which exhibits bistability when all the protein species are conserved, is not structurally stable when degradation and synthesis of one of the components are taken into account.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | isogenic cells |
| Subjects: | Q Science > QA Mathematics |
| Divisions: | Science |
| ID Code: | 73208 |
| Deposited By: | Muhammad Atiff Mahussain |
| Deposited On: | 29 Nov 2017 23:58 |
| Last Modified: | 29 Nov 2017 23:58 |
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