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In vivo irritation study of Melastoma malabathricum cream formulation on ICR mice

Yasin, R. A. M. and Jemon, K. and Nor, N. S. M. (2016) In vivo irritation study of Melastoma malabathricum cream formulation on ICR mice. In: 2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016, 13 April 2016 through 14 April 2016, Selangor; Malaysia.

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Abstract

Melastoma malabathricum is a traditional herb that is used to treat wound on skin. It has also been proven to have antiviral activity against Herpes Simplex virus type 1 (HSV-1). In this study, M. malabathricum cream formulation was developed by incorporating M. malabathricum aqueous extract into cream base. The safety and biocompatibility of the formulated cream was investigated by topically applying the cream onto the back of ICR mice skin. Treatment with M. malabathricum was found to accelerate wound contraction with less scar formation. The effect of M. malabathricum has prompted a possibility that M. malabathricum might contribute in enhancing the healing process of cutaneous lesion caused by HSV-1. The formulated cream did not cause any skin irritation or adverse effect to ICR mice when topically applied within seven days of exposure.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:scar formation
Subjects:Q Science > QH Natural history
Divisions:Biosciences and Medical Engineering
ID Code:72963
Deposited By: Muhammad Atiff Mahussain
Deposited On:27 Nov 2017 10:00
Last Modified:27 Nov 2017 10:00

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