On, S. and Aminudin, N. I. and Ahmad, F. and Sirat, H. M. and Taher, M. (2016) Chemical constituents from stem bark of Garcinia prainiana and their bioactivities. International Journal of Pharmacognosy and Phytochemical Research, 8 (5). pp. 756-760. ISSN 0975-4873
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Abstract
Phytochemical investigations on the hexane and methanol extracts of the dried stem barks of Garcinia prainiana resulted in the isolation of two triterpenes; 3β-hydroxyeupha-5,22-diene (1), 3β-acetoxyeupha-5,22-diene (2) as well as five flavonoids, morelloflavone (3), O-methylfukugetin (4), volkensiflavone (5), amentoflavone (6) and 4‴-methoxyamentoflavone (7). Except for (3) and (5), the rest of the isolated compounds are reported here for the first time from this plant. The structures were established based on spectral analyses. The crudes and compounds were screened for DPPH radical scavenging assay and tyrosinase inhibition activity. The methanol extract and compound (3) were found to show high radical scavenging activity with IC50 15.1 and 15.7 μg/mL, respectively. As for tyrosinase inhibition assay, compound (3) was found to exhibit the highest activity with IC50 34.0 μg/mL.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1,1 diphenyl 2 picrylhydrazyl, 3 beta acetoxyeupha 5,22 diene, 3 beta hydroxyeupha 5,22 diene, 4 methoxyamentoflavone, amentoflavone, biflavaboid, flavonoid, Garcinia prainiana extract, hexane, kojic acid, methanol, monophenol monooxygenase, morelloflavone, o methylfukugetin, plant extract, triterpene derivative, unclassified drug, volkensiflavone, antibacterial activity, antioxidant activity, Article, Bacillus subtilis, bark, chemical composition, controlled study, drug isolation, drug screening, drug structure, enzyme activity, enzyme inhibition, Escherichia coli, Garcinia prainiana, IC50, minimum inhibitory concentration, nonhuman, phytochemistry, plant stem, Pseudomonas aeruginosa, spectroscopy, Staphylococcus aureus |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Science |
| ID Code: | 72570 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 27 Nov 2017 00:36 |
| Last Modified: | 27 Nov 2017 00:36 |
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