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Synthesis, characterization, and cytotoxic activities of heterocyclic chalcones containing furan, and crystal structure of 1-(4-iodophenyl)-3-(5-methylfuran-2-yl)prop-2-en-1-one

Mokhtar, Z. and Jamalis, J. and Bohari, S. P. M. and Rosli, M. M. and Fun, H. K. (2016) Synthesis, characterization, and cytotoxic activities of heterocyclic chalcones containing furan, and crystal structure of 1-(4-iodophenyl)-3-(5-methylfuran-2-yl)prop-2-en-1-one. Molecular Crystals and Liquid Crystals, 631 (1). pp. 119-131. ISSN 1542-1406

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Abstract

A series of heterocyclic chalcone (3a–e, 5, 7) were synthesized and characterized by Infrared, 1H and 13C nuclear magnetic resonance, and mass spectra. Crystal structure of 1-(4-iodophenyl)-3-(5-methylfuran-2-yl)prop-2-en-1-one was determined using single crystal X-ray diffraction. All the synthesized compounds were evaluated for their cytotoxic activities on MDA MB 231 and CHO cell by using MTT assay. Compound 3c showed good cytotoxic effect on MDA MB 231 with IC50 values of 9.8 µg/mL.

Item Type:Article
Uncontrolled Keywords:Cytotoxicity, Mass spectrometry, Organic compounds, Single crystals, Synthesis (chemical), X ray diffraction, 4-iodophenyl, Breast Cancer, Chalcones, Cytotoxic activities, Cytotoxic effects, Mass spectra, MDA-MB-231, Single crystal x-ray diffraction, Crystal structure
Subjects:Q Science > QC Physics
Divisions:Science
ID Code:72526
Deposited By: Haliza Zainal
Deposited On:28 Nov 2017 12:13
Last Modified:28 Nov 2017 12:13

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